CCBE1 Polyclonal Antibody, 50ul Biochemical Reagents CDKN2A (cyclin dependent kinase inhibitor

CDKN2A (cyclin dependent kinase inhibitor 2A) generates several transcript variants which differ in their first exons

it lacks the conserved His residue which is normally found 9 residues before the catalytic His

and this activation is strictly dependent on an intact T1R1+3 heterodimer

The testicular form is expressed in embryonic tissues

and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins

CCBE1 Polyclonal Antibody, 50ul Biochemical Reagents CDKN2A (cyclin dependent kinase inhibitorThis gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia lymphedema syndrome, a generalized lymphatic dysplasia in humans.